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Regenerative Medicine in Rotator Cuff Injuries
Joint Authors
Randelli, Pietro
Ragone, Vincenza
Cabitza, Paolo
Menon, Alessandra
Banfi, Giuseppe
Randelli, Filippo
D’Ambrosi, Riccardo
Cucchi, Davide
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rotator cuff injuries are a common source of shoulder pathology and result in an important decrease in quality of patient life.
Given the frequency of these injuries, as well as the relatively poor result of surgical intervention, it is not surprising that new and innovative strategies like tissue engineering have become more appealing.
Tissue-engineering strategies involve the use of cells and/or bioactive factors to promote tendon regeneration via natural processes.
The ability of numerous growth factors to affect tendon healing has been extensively analyzed in vitro and in animal models, showing promising results.
Platelet-rich plasma (PRP) is a whole blood fraction which contains several growth factors.
Controlled clinical studies using different autologous PRP formulations have provided controversial results.
However, favourable structural healing rates have been observed for surgical repair of small and medium rotator cuff tears.
Cell-based approaches have also been suggested to enhance tendon healing.
Bone marrow is a well known source of mesenchymal stem cells (MSCs).
Recently, ex vivo human studies have isolated and cultured distinct populations of MSCs from rotator cuff tendons, long head of the biceps tendon, subacromial bursa, and glenohumeral synovia.
Stem cells therapies represent a novel frontier in the management of rotator cuff disease that required further basic and clinical research.
American Psychological Association (APA)
Randelli, Pietro& Randelli, Filippo& Ragone, Vincenza& Menon, Alessandra& D’Ambrosi, Riccardo& Cucchi, Davide…[et al.]. 2014. Regenerative Medicine in Rotator Cuff Injuries. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-448002
Modern Language Association (MLA)
Randelli, Pietro…[et al.]. Regenerative Medicine in Rotator Cuff Injuries. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-448002
American Medical Association (AMA)
Randelli, Pietro& Randelli, Filippo& Ragone, Vincenza& Menon, Alessandra& D’Ambrosi, Riccardo& Cucchi, Davide…[et al.]. Regenerative Medicine in Rotator Cuff Injuries. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-448002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448002