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Early Therapeutic Drug Monitoring for Isoniazid and Rifampin among Diabetics with Newly Diagnosed Tuberculosis in Virginia, USA
Joint Authors
Staley, Debbie
Moore, Jane L.
Dodge, Denise
Houpt, Eric R.
Heysell, Scott K.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Slow responders to tuberculosis (TB) treatment in Virginia have prolonged treatment duration and consume more programmatic resources.
Diabetes is an independent risk factor for slow response and low serum anti-TB drug concentrations.
Thus, a statewide initiative of early therapeutic drug monitoring (TDM) for isoniazid and rifampin at 2 weeks after TB treatment was piloted for all diabetics with newly diagnosed TB.
During the period of early TDM, 12/01/2011–12/31/2012, 21 diabetics had C2 hr concentrations performed and 16 (76%) had a value below the expected range for isoniazid, rifampin, or both.
Fifteen had follow-up concentrations after dose adjustment and 12 (80%) increased to within the expected range (including all for rifampin).
Of 16 diabetic patients with pulmonary TB that had early TDM, 14 (88%) converted their sputum culture to negative in <2 months.
Early TDM for diabetics was operationally feasible, may speed response to TB therapy, and can be considered for TB programs with high diabetes prevalence.
American Psychological Association (APA)
Heysell, Scott K.& Moore, Jane L.& Staley, Debbie& Dodge, Denise& Houpt, Eric R.. 2013. Early Therapeutic Drug Monitoring for Isoniazid and Rifampin among Diabetics with Newly Diagnosed Tuberculosis in Virginia, USA. Tuberculosis Research and Treatment،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-448030
Modern Language Association (MLA)
Heysell, Scott K.…[et al.]. Early Therapeutic Drug Monitoring for Isoniazid and Rifampin among Diabetics with Newly Diagnosed Tuberculosis in Virginia, USA. Tuberculosis Research and Treatment No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-448030
American Medical Association (AMA)
Heysell, Scott K.& Moore, Jane L.& Staley, Debbie& Dodge, Denise& Houpt, Eric R.. Early Therapeutic Drug Monitoring for Isoniazid and Rifampin among Diabetics with Newly Diagnosed Tuberculosis in Virginia, USA. Tuberculosis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-448030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448030