Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil
Joint Authors
Jemaà, Mohamed
Senovilla, Laura
Fezai, Myriam
Ben-Attia, Mossadok
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
In folk medicine, extra virgin olive oil (EVOO) is used as a remedy for a variety of diseases.
This study investigates the in vivo antinociceptive, anti-inflammatory, and anti-cancer effects of EVOO on mice and rats.
Materials and Methods.
In this experimental study, using the acetic acid-induced writhing and formalin tests in mice, the analgesic effect of EVOO was evaluated.
Acetylsalicylic acid and morphine were used as standard drugs, respectively.
The anti-inflammatory activity was investigated by means of the carrageenan-induced paw edema model in rats using acetylsalicylic acid and dexamethasone as standard drugs.
Last, the xenograft model in athymic mice was used to evaluate the anticancer effect in vivo.
Results.
EVOO significantly decreased acetic acid-induced abdominal writhes and reduces acute and inflammatory pain in the two phases of the formalin test.
It has also a better effect than Dexamethasone in the anti-inflammatory test.
Finally, the intraperitoneal administration of EVOO affects the growth of HCT 116 tumours xenografted in athymic mice.
Conclusion.
EVOO has a significant analgesic, anti-inflammatory, and anticancer properties.
However, further detailed studies are required to determine the active component responsible for these effects and mechanism pathway.
American Psychological Association (APA)
Fezai, Myriam& Senovilla, Laura& Jemaà, Mohamed& Ben-Attia, Mossadok. 2013. Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil. Journal of Lipids،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-448033
Modern Language Association (MLA)
Fezai, Myriam…[et al.]. Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil. Journal of Lipids No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-448033
American Medical Association (AMA)
Fezai, Myriam& Senovilla, Laura& Jemaà, Mohamed& Ben-Attia, Mossadok. Analgesic, Anti-Inflammatory and Anticancer Activities of Extra Virgin Olive Oil. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-448033
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448033