Monocyte Chemoattractant Protein-1− 2518 AG Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLE
Joint Authors
Jagodziński, Paweł P.
Roszak, Andrzej
Gasik, Robert
Piotrowski, Piotr
Lianeri, Margarita
Olesińska, Marzena
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There is conflicting evidence on the contribution of the MCP-1 −2518 A>G (rs 1024611) polymorphism to SLE incidence and clinical manifestations.
We examined the prevalence of the MCP-1 −2518 A>G polymorphism in SLE patients (n=199) and controls (n=250) in Poland.
We did not observe a significant difference in the distribution of MCP-1 −2518 A>G polymorphic variants in patients with SLE and healthy individuals.
However, we found an association between the GG versus AG and AA genotypes as well as the AG and GG versus AA genotypes with renal manifestations of SLE OR=3.614 (1.123–11.631, P=0.0345) and OR=2.297 (1.301–4.057, P=0.0046), respectively.
We also observed that the MCP-1 AG and GG -genotypes contribute to the occurrence of thrombocytopenia in SLE patients OR=2.618 (1.280–5.352, P=0.0089).
Our observations indicate that either MCP-1 −2518 G variant can be associated with some clinical findings in patients with SLE.
American Psychological Association (APA)
Piotrowski, Piotr& Lianeri, Margarita& Gasik, Robert& Roszak, Andrzej& Olesińska, Marzena& Jagodziński, Paweł P.. 2010. Monocyte Chemoattractant Protein-1− 2518 AG Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLE. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-448058
Modern Language Association (MLA)
Piotrowski, Piotr…[et al.]. Monocyte Chemoattractant Protein-1− 2518 AG Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLE. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-448058
American Medical Association (AMA)
Piotrowski, Piotr& Lianeri, Margarita& Gasik, Robert& Roszak, Andrzej& Olesińska, Marzena& Jagodziński, Paweł P.. Monocyte Chemoattractant Protein-1− 2518 AG Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLE. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-448058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448058