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The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice
Joint Authors
Caruncho, Héctor J.
Kalynchuk, Lisa E.
Romay-Tallón, Raquel
Lussier, April L.
Dopeso-Reyes, Iria G.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Reelin is an extracellular matrix protein expressed in several interneuron subtypes in the hippocampus and dentate gyrus.
Neuronal nitric oxide synthase (nNOS) is also expressed by interneurons in these areas.
We investigated whether reelin and nNOS are co-localized in the same population of hippocampal interneurons, and whether this colocalization is altered in the heterozygous reeler mouse.
We found colocalization of nNOS in reelin-positive cells in the CA1 stratum radiatum and lacunosum moleculare, the CA3 stratum radiatum, and the dentate gyrus subgranular zone, molecular layer, and hilus.
In heterozygous reeler mice, the colocalization of nNOS in reelin-positive cells was significantly decreased only in the subgranular zone and molecular layer.
The coexpression of reelin and nNOS in several hippocampal regions suggests that reelin and nNOS may work synergistically to promote glutamatergic function, and the loss of this coexpression in heterozygous reeler mice may underlie some of the behavioral deficits observed in these animals.
American Psychological Association (APA)
Romay-Tallón, Raquel& Dopeso-Reyes, Iria G.& Lussier, April L.& Kalynchuk, Lisa E.& Caruncho, Héctor J.. 2010. The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice. Neural Plasticity،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-448073
Modern Language Association (MLA)
Romay-Tallón, Raquel…[et al.]. The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice. Neural Plasticity No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-448073
American Medical Association (AMA)
Romay-Tallón, Raquel& Dopeso-Reyes, Iria G.& Lussier, April L.& Kalynchuk, Lisa E.& Caruncho, Héctor J.. The Coexpression of Reelin and Neuronal Nitric Oxide Synthase in a Subpopulation of Dentate Gyrus Neurons Is Downregulated in Heterozygous Reeler Mice. Neural Plasticity. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-448073
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448073