Network Analysis of Functional Genomics Data : Application to Avian Sex-Biased Gene Expression
Joint Authors
Alexeyenko, Andrey
Mank, Judith E.
Frings, Oliver
Sonnhammer, Erik L. L.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Gene expression analysis is often used to investigate the molecular and functional underpinnings of a phenotype.
However, differential expression of individual genes is limited in that it does not consider how the genes interact with each other in networks.
To address this shortcoming we propose a number of network-based analyses that give additional functional insights into the studied process.
These were applied to a dataset of sex-specific gene expression in the chicken gonad and brain at different developmental stages.
We first constructed a global chicken interaction network.
Combining the network with the expression data showed that most sex-biased genes tend to have lower network connectivity, that is, act within local network environments, although some interesting exceptions were found.
Genes of the same sex bias were generally more strongly connected with each other than expected.
We further studied the fates of duplicated sex-biased genes and found that there is a significant trend to keep the same pattern of sex bias after duplication.
We also identified sex-biased modules in the network, which reveal pathways or complexes involved in sex-specific processes.
Altogether, this work integrates evolutionary genomics with systems biology in a novel way, offering new insights into the modular nature of sex-biased genes.
American Psychological Association (APA)
Frings, Oliver& Mank, Judith E.& Alexeyenko, Andrey& Sonnhammer, Erik L. L.. 2012. Network Analysis of Functional Genomics Data : Application to Avian Sex-Biased Gene Expression. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448081
Modern Language Association (MLA)
Frings, Oliver…[et al.]. Network Analysis of Functional Genomics Data : Application to Avian Sex-Biased Gene Expression. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-448081
American Medical Association (AMA)
Frings, Oliver& Mank, Judith E.& Alexeyenko, Andrey& Sonnhammer, Erik L. L.. Network Analysis of Functional Genomics Data : Application to Avian Sex-Biased Gene Expression. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448081