Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus
Joint Authors
Ee, Gwendoline Cheng Lian
Sukari, Mohd Aspollah
Yahayu, Maizatulakmal
Go, Rusea
Oktima, Winda
Ali, Abdul Manaf
Hashim, Najihah Mohd
Rahmani, Mawardi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
An investigation of the chemical constituents in Artocarpus obtusus species led to the isolation of three new xanthones, pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2), and pyranocycloartobiloxanthone B (3).
The compounds were subjected to antiproliferative assay against human promyelocytic leukemia (HL60), human chronic myeloid leukemia (K562), and human estrogen receptor (ER+) positive breast cancer (MCF7) cell lines.
Pyranocycloartobiloxanthone A (1) consistently showed strong cytotoxic activity against the three cell lines compared to the other two with IC50 values of 0.5, 2.0 and 5.0 μg/mL, respectively.
Compound (1) was also observed to exert antiproliferative activity and apoptotic promoter towards HL60 and MCF7 cell lines at respective IC50 values.
The compound (1) was not toxic towards normal cell lines human nontumorigenic breast cell line (MCF10A) and human peripheral blood mononuclear cells (PBMCs) with IC50 values of more than 30 μg/mL.
American Psychological Association (APA)
Hashim, Najihah Mohd& Rahmani, Mawardi& Ee, Gwendoline Cheng Lian& Sukari, Mohd Aspollah& Yahayu, Maizatulakmal& Oktima, Winda…[et al.]. 2011. Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448102
Modern Language Association (MLA)
Hashim, Najihah Mohd…[et al.]. Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-448102
American Medical Association (AMA)
Hashim, Najihah Mohd& Rahmani, Mawardi& Ee, Gwendoline Cheng Lian& Sukari, Mohd Aspollah& Yahayu, Maizatulakmal& Oktima, Winda…[et al.]. Antiproliferative Activity of Xanthones Isolated from Artocarpus obtusus. Journal of Biomedicine and Biotechnology. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448102
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448102