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Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases
Joint Authors
Montero, Enrique
Loisel, Séverine
Buors, Caroline
Youinou, Pierre
Pers, Jacques-Olivier
Renaudineau, Yves
Alonso-Ramirez, Ruby
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CD6 is a 105–130 kDa surface glycoprotein expressed on the majority of T cells and a subset of B cells.
The human cd6 gene maps to chromosome 11, and the expression of its protein product is tightly regulated.
CD6 mediates cellular adhesion migration across the endothelial and epithelial cells.
In addition, it participates in the antigen presentation by B cells and the subsequent proliferation of T cells.
CD6 may bind in trans to surface glycoproteins (such as ALCAM and 3A11), or to microbial lipopolysaccharides, and may bind in cis to endogenous ligands (such as CD3 and CD5), and thereby deliver a costimulatory signal.
Transinteractions are reinforced during autoimmune diseases (e.g., rheumatoid arthritis (RA), Sjögren's syndrome, and multiple sclerosis) and some cancers.
Based on experimental data and on clinical results in RA and psoriasis, we believe that the recent humanized anti-CD6-specific mAb T1h may act as a regulator of the immunological response in addition to its function as an anti-T- and -B cell agent.
American Psychological Association (APA)
Alonso-Ramirez, Ruby& Loisel, Séverine& Buors, Caroline& Pers, Jacques-Olivier& Montero, Enrique& Youinou, Pierre…[et al.]. 2011. Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases. Arthritis،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-448105
Modern Language Association (MLA)
Alonso-Ramirez, Ruby…[et al.]. Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases. Arthritis No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-448105
American Medical Association (AMA)
Alonso-Ramirez, Ruby& Loisel, Séverine& Buors, Caroline& Pers, Jacques-Olivier& Montero, Enrique& Youinou, Pierre…[et al.]. Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases. Arthritis. 2011. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-448105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448105