Pilot Study of Inhaled Aerosols Targeted via Magnetic Alignment of High Aspect Ratio Particles in Rabbits
Joint Authors
Thompson, Richard B.
Finlay, Warren H.
Martin, Andrew R.
Redman, Gillian E. S.
Thébaud, Bernard
Cheung, Po-Yin
Waszak, Paul
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Recently, inhaled pharmaceutical aerosols have seen increased investigation in the treatment of lung cancer, where the inability to deliver adequate therapeutic drug concentrations to tumour sites may be overcome with improved targeted delivery to the site of the tumour.
In this study, the feasibility of magnetically targeted delivery of high aspect ratio particles loaded with iron oxide nanoparticles was studied in 19 New Zealand White rabbits.
Half of the exposed rabbits had a magnetic field placed externally over their right lung.
Iron sensitive magnetic resonance images of the lungs were acquired to determine the iron concentrations in the right and left lung of each animal.
The right/left ratio increased in the middle and basal regions of the lung where, due to the morphology of the rabbit lung, this method of targeting is most effective.
With further optimization, this technique could be an effective method for increasing the dose of drug delivered to a specific site within the lung.
American Psychological Association (APA)
Redman, Gillian E. S.& Martin, Andrew R.& Waszak, Paul& Thompson, Richard B.& Cheung, Po-Yin& Thébaud, Bernard…[et al.]. 2010. Pilot Study of Inhaled Aerosols Targeted via Magnetic Alignment of High Aspect Ratio Particles in Rabbits. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-448115
Modern Language Association (MLA)
Redman, Gillian E. S.…[et al.]. Pilot Study of Inhaled Aerosols Targeted via Magnetic Alignment of High Aspect Ratio Particles in Rabbits. Journal of Nanomaterials No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-448115
American Medical Association (AMA)
Redman, Gillian E. S.& Martin, Andrew R.& Waszak, Paul& Thompson, Richard B.& Cheung, Po-Yin& Thébaud, Bernard…[et al.]. Pilot Study of Inhaled Aerosols Targeted via Magnetic Alignment of High Aspect Ratio Particles in Rabbits. Journal of Nanomaterials. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-448115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448115