Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats
Joint Authors
Mathias, Francielle Tatiane
Romano, Marco Aurelio
Sleiman, Hanan Kaled
Romano, Renata Marino
de Oliveira, Claudio Alvarenga
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
S-metolachlor is a chloroacetanilide herbicide widely used in the agriculture to control weeds and was demonstrated that it increases the activity of the aromatase enzyme in cell cultures, which may culminate as endocrine disruption action in vivo.
To investigate this hypothesis, prepubertal Wistar male rats were exposed to metolachlor (5 or 50 mg/kg/day, NOEL for reproductive toxicity: 23.5–26.0 mg/kg/day) from PND23 (postnatal day) to PND53.
During this period, the growth of the animals and the age and weight at puberty were recorded.
In PND53, tissues were collected and the analysis of LH, FSH, testosterone, dihydrotestosterone (DHT), estradiol serum concentrations, morphometric evaluation of the seminiferous epithelium, and weight of the testes and the seminal vesicle (undrained and drained) was performed (Statistical difference: P<0.05).
Metolachlor caused an increase in serum concentrations of testosterone, estradiol, and FSH and a reduction in DHT but did not alter the LH.
There were also observed a higher amount of fluid in the seminal vesicles, precocious puberty, and changes in morphology of the seminiferous epithelium of treated animals.
We demonstrated in this paper that prepubertal exposure to S-metolachlor caused changes in reproductive endocrinology of male rats.
American Psychological Association (APA)
Mathias, Francielle Tatiane& Romano, Renata Marino& Sleiman, Hanan Kaled& de Oliveira, Claudio Alvarenga& Romano, Marco Aurelio. 2012. Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats. ISRN Toxicology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448131
Modern Language Association (MLA)
Mathias, Francielle Tatiane…[et al.]. Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats. ISRN Toxicology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-448131
American Medical Association (AMA)
Mathias, Francielle Tatiane& Romano, Renata Marino& Sleiman, Hanan Kaled& de Oliveira, Claudio Alvarenga& Romano, Marco Aurelio. Herbicide Metolachlor Causes Changes in Reproductive Endocrinology of Male Wistar Rats. ISRN Toxicology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448131
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448131