The Microbiological Context of HIV Resistance : Vaginal Microbiota and Mucosal Inflammation at the Viral Point of Entry
Joint Authors
Plummer, Francis A.
Schellenberg, John J.
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Immune activation is increasingly recognized as a critical element of HIV infection and pathogenesis, causing expansion of virus founder populations at the mucosal port of entry and eventual exhaustion of cellular immune effectors.
HIV susceptibility is well known to be influenced by concurrent sexually transmitted infections; however, the role of commensal vaginal microbiota is poorly characterized.
Bacterial vaginosis (BV) is a risk factor for HIV acquisition in studies worldwide; however, the etiology of BV remains enigmatic, and the mechanisms by which BV increases HIV susceptibility are not fully defined.
A model of how vaginal microbiota influences HIV transmission is considered in the context of a well-established cohort of HIV-exposed seronegative (HESN) commercial sex workers (CSW) in Nairobi, Kenya, many of whom have increased levels of anti-inflammatory factors in vaginal secretions and reduced peripheral immune activation (immune quiescence).
Elucidation of the relationship between complex microbial communities and inflammatory mucosal responses underlying HIV infection should be a priority for future prevention-focussed research.
American Psychological Association (APA)
Schellenberg, John J.& Plummer, Francis A.. 2012. The Microbiological Context of HIV Resistance : Vaginal Microbiota and Mucosal Inflammation at the Viral Point of Entry. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448161
Modern Language Association (MLA)
Schellenberg, John J.& Plummer, Francis A.. The Microbiological Context of HIV Resistance : Vaginal Microbiota and Mucosal Inflammation at the Viral Point of Entry. International Journal of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-448161
American Medical Association (AMA)
Schellenberg, John J.& Plummer, Francis A.. The Microbiological Context of HIV Resistance : Vaginal Microbiota and Mucosal Inflammation at the Viral Point of Entry. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448161