Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine
Joint Authors
Seo, Ean-Jeong
Kuete, Victor
Kadioglu, Onat
Efferth, Thomas
Lee, Ik-Soo
Krusche, Benjamin
Schroeder, Sven
Arend, Joachim
Greten, Henry Johannes
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Aim.
In the present study, we investigated the antiangiogenic properties of 59 plants used in traditional Korean medicine.
Selected phytochemicals were investigated in more detail for their modes of action.
Methods.
A modified chicken-chorioallantoic-membrane (CAM) assay using quail eggs was applied to test for antiangiogenic effects of plant extracts.
A molecular docking in silico approached the binding of plant constituents to the vascular endothelial growth factor receptors 1 and 2 (VEGFR1, VEGFR2).
Microarray-based mRNA expression profiling was employed to correlate the 50% inhibition concentrations (IC50) of a panel of 60 NCI cell lines to these phytochemicals.
Results.
Extracts from Acer mono leaves, Reynoutria sachalniensis fruits, Cinnamomum japonicum stems, Eurya japonica leaves, Adenophora racemosa whole plant, Caryopteris incana leaves-stems, and Schisandra chinensis stems inhibited angiogenesis more than 50% in quail eggs.
Selected phytochemicals from Korean plants were analyzed in more detail using microarray-based mRNA expression profiles and molecular docking to VEGFR1 and VEGFR2.
These results indicate multifactorial modes of action of these natural products.
Conclusion.
The antiangiogenic activity of plants used in traditional Korean medicine implicates their possible application for diseases where inhibition of blood vessel formation is desired, for example, cancer, macular degeneration, diabetic retinopathy and others.
American Psychological Association (APA)
Seo, Ean-Jeong& Kuete, Victor& Kadioglu, Onat& Krusche, Benjamin& Schroeder, Sven& Greten, Henry Johannes…[et al.]. 2013. Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-448162
Modern Language Association (MLA)
Seo, Ean-Jeong…[et al.]. Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-448162
American Medical Association (AMA)
Seo, Ean-Jeong& Kuete, Victor& Kadioglu, Onat& Krusche, Benjamin& Schroeder, Sven& Greten, Henry Johannes…[et al.]. Antiangiogenic Activity and Pharmacogenomics of Medicinal Plants from Traditional Korean Medicine. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-448162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448162