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Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes
Joint Authors
Abdualmjid, Reem
Abuetabh, Yasser
Sergi, Consolato
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Liver transplantation has been a successful therapy for liver failure.
However, a significant number of recipients suffer from graft dysfunction.
Considerably, ischemia and reperfusion (I/R) injury is the most important factor leading to organ dysfunction, although the pathogenesis has not been fully described.
I/R injury have several established features that are accompanied by and/or linked to bile duct loss or ductopenia, cholestasis, and biliary ductular proliferations in the posttransplant liver biopsy.
However, biliary marker levels increase usually only 5–7 days after transplantation.
Intermediate filaments are one of the three cytoskeletal proteins that have a major role in liver protection and maintaining both cellular structure and integrity of eukaryotic cells.
We reviewed the canine liver transplantation model as I/R injury model to delineate the intermediate filaments of the cytoskeleton that are probably the determinants in changing the phenotype of hepatocytes to cholangiocytes.
Remarkably, this interesting feature seems to occur earlier than frank cholestasis.
We speculate that I/R liver injury through a phenotypical switch of the hepatocytes may contribute to the poor outcome of the liver graft.
American Psychological Association (APA)
Sergi, Consolato& Abdualmjid, Reem& Abuetabh, Yasser. 2012. Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-448163
Modern Language Association (MLA)
Sergi, Consolato…[et al.]. Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-448163
American Medical Association (AMA)
Sergi, Consolato& Abdualmjid, Reem& Abuetabh, Yasser. Canine Liver Transplantation Model and the Intermediate Filaments of the Cytoskeleton of the Hepatocytes. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-448163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448163