Lipid Emulsion for Local Anesthetic Systemic Toxicity
Joint Authors
Ciechanowicz, Sarah
Patil, Vinod
Source
Anesthesiology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The accidental overdose of local anesthetics may prove fatal.
The commonly used amide local anesthetics have varying adverse effects on the myocardium, and beyond a certain dose all are capable of causing death.
Local anesthetics are the most frequently used drugs amongst anesthetists and although uncommon, local anaesthetic systemic toxicity accounts for a high proportion of mortality, with local anaesthetic-induced cardiac arrest particularly resistant to standard resuscitation methods.
Over the last decade, there has been convincing evidence of intravenous lipid emulsions as a rescue in local anesthetic-cardiotoxicity, and anesthetic organisations, over the globe have developed guidelines on the use of this drug.
Despite this, awareness amongst practitioners appears to be lacking.
All who use local anesthetics in their practice should have an appreciation of patients at high risk of toxicity, early symptoms and signs of toxicity, preventative measures when using local anesthetics, and the initial management of systemic toxicity with intravenous lipid emulsion.
In this paper we intend to discuss the pharmacology and pathophysiology of local anesthetics and toxicity, and the rationale for lipid emulsion therapy.
American Psychological Association (APA)
Ciechanowicz, Sarah& Patil, Vinod. 2011. Lipid Emulsion for Local Anesthetic Systemic Toxicity. Anesthesiology Research and Practice،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448196
Modern Language Association (MLA)
Ciechanowicz, Sarah& Patil, Vinod. Lipid Emulsion for Local Anesthetic Systemic Toxicity. Anesthesiology Research and Practice No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-448196
American Medical Association (AMA)
Ciechanowicz, Sarah& Patil, Vinod. Lipid Emulsion for Local Anesthetic Systemic Toxicity. Anesthesiology Research and Practice. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-448196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448196