Limited Therapeutic Time Windows of Mild-to-Moderate Hypothermia in a Focal Ischemia Model in Rat
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Although many studies have shown the great potential of induced hypothermia in stroke treatment, we recognize that there are limitations to the protective effects of hypothermia even in the laboratory.
Here, we review our experiments on the protective effects of mild-to-moderate hypothermia in rats.
Focal ischemia was induced by bilateral common carotid artery (CCA) occlusion for 1 to 2 hours combined with permanent or transient middle cerebral artery (MCA) occlusion.
We compared the effects of mild (33∘C) and moderate (30∘C) hypothermia, evaluated therapeutic time windows, and studied the underlying mechanisms.
On review, our findings revealed that the protective effects of induced mild hypothermia (33∘C) were limited, and the therapeutic time window of even moderate hypothermia (30∘C) was very short in our specific models, although this limitation might be due to the relatively brief periods of hypothermia used.
In addition, we found that hypothermia reduced brain injury by preserving Akt activity, PTEN phosphorylation and εPKC activity, while inhibiting ROS production, and δPKC activity.
American Psychological Association (APA)
Zhao, Heng& Steinberg, Gary. 2011. Limited Therapeutic Time Windows of Mild-to-Moderate Hypothermia in a Focal Ischemia Model in Rat. Stroke Research and Treatment،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-448201
Modern Language Association (MLA)
Zhao, Heng& Steinberg, Gary. Limited Therapeutic Time Windows of Mild-to-Moderate Hypothermia in a Focal Ischemia Model in Rat. Stroke Research and Treatment No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-448201
American Medical Association (AMA)
Zhao, Heng& Steinberg, Gary. Limited Therapeutic Time Windows of Mild-to-Moderate Hypothermia in a Focal Ischemia Model in Rat. Stroke Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-448201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448201