Helicobacter pylori Infection and Risk of Lung Cancer : A Meta-Analysis
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Recent evidence showed that Helicobacter pylori seropositivity is a risk factor for gastric and several other cancers.
However, evidence on H.
pylori infection and risk of lung cancer has been controversial, with a limited number of underpowered studies.
We therefore examined the association between H.
pylori infection and risk of lung cancer.
Methods.
A comprehensive literature search was performed using PubMed, EMBASE (until October 2012) for studies investigating an association between Helicobacter pylori (H.
pylori) infection and risk of lung cancer.
Pooled odds ratio (OR) was calculated using random-effects model.
Subgroup and sensitivity analysis were also done.
Results.
A total of seven studies (6 case-control and 1 cohort study) were included for the analysis.
There was a significant heterogeneity among the studies, but no publication bias was observed.
We found that H.
pylori infection was associated with significantly increased risk of lung cancer (pooled OR, 2.29 (95% CI, 1.34–3.91) P=0.01).
Conclusions.
Our meta-analysis suggests a significant increased risk of lung cancer in patients with H.
pylori infection.
Further research is needed to confirm these findings and to identify the underlying biological mechanisms.
American Psychological Association (APA)
Mounika, Pulikonda. 2013. Helicobacter pylori Infection and Risk of Lung Cancer : A Meta-Analysis. Lung Cancer International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-448206
Modern Language Association (MLA)
Mounika, Pulikonda. Helicobacter pylori Infection and Risk of Lung Cancer : A Meta-Analysis. Lung Cancer International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-448206
American Medical Association (AMA)
Mounika, Pulikonda. Helicobacter pylori Infection and Risk of Lung Cancer : A Meta-Analysis. Lung Cancer International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-448206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448206