![](/images/graphics-bg.png)
The Effects of Forodesine in Murine and Human Multiple Myeloma Cells
Joint Authors
Menu, Eline
Bieghs, Liesbeth
Van Valckenborgh, Els
Caers, Jo
Vanderkerken, Karin
Higginbotham, Fiona
De Bruyne, Elke
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Multiple myeloma (MM) is the second most commonly diagnosed hematological malignancy, characterized by a monoclonal proliferation of malignant cells in the bone marrow.
Despite recent advances in treatment strategies, MM remains incurable and new therapeutical targets are needed.
Recently forodesine, a purine nucleoside phosphorylase inhibitor, was found to induce apoptosis in leukemic cells of chronic lymphocytic leukemia patients by increasing the dGTP levels.
We therefore tested whether forodesine was able to inhibit proliferation and/or induce apoptosis in both murine and human MM cells through a similar pathway.
We found that after 48 hours of treatment with forodesine there was a slight dGTP increase in 5T33MM and RPMI-8226 MM cells associated with partial inhibition of proliferation and a limited induction of apoptosis.
When investigating the pathways leading to cell cycle arrest and apoptosis, we observed an upregulation of p27, caspase 3, and BIM.
We can conclude that forodesine has some effects on MM cells but not as impressive as the known effects in leukemic cells.
Forodesine might be however potentiating towards other established cytotoxic drugs in MM.
American Psychological Association (APA)
Bieghs, Liesbeth& Caers, Jo& De Bruyne, Elke& Van Valckenborgh, Els& Higginbotham, Fiona& Vanderkerken, Karin…[et al.]. 2010. The Effects of Forodesine in Murine and Human Multiple Myeloma Cells. Advances in Hematology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-448209
Modern Language Association (MLA)
Bieghs, Liesbeth…[et al.]. The Effects of Forodesine in Murine and Human Multiple Myeloma Cells. Advances in Hematology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-448209
American Medical Association (AMA)
Bieghs, Liesbeth& Caers, Jo& De Bruyne, Elke& Van Valckenborgh, Els& Higginbotham, Fiona& Vanderkerken, Karin…[et al.]. The Effects of Forodesine in Murine and Human Multiple Myeloma Cells. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-448209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448209