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Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form
Joint Authors
Jadhav, Namdeo R.
Nadaf, Sameer J.
Kambar, Ramesh S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Atorvastatin calcium (ATR) and felodipine (FEL) are beneficial in combination for elderly people in management of hypertension and atherosclerosis.
Aim of present study is to develop simple, accurate, and precise method for simultaneous quantitative estimation of ATR and FEL from combined tablet dosage form.
Method involves simultaneous equation, using acetonitrile—double distilled water (70 : 30)—common solvent showing absorption maxima at 245 and 268 nm.
Calibration curves determination for both drugs has been carried out in 0.1 N HCl, phosphate buffer pH 6.8, and acetonitrile (ACN)—water (70 : 30 V/V).
Linearity range was observed in the concentration range of 2 to 12 µg/mL for FEL and 20 to 100 µg/mL for ATR.
Percent concentration estimated for ATR and FEL was 100.12 ± 1.03 and 99.98 ± 0.98, respectively.
The method was found to be simple, economical, accurate and precise and can be used for quantitative estimation of ATR and FEL.
American Psychological Association (APA)
Jadhav, Namdeo R.& Kambar, Ramesh S.& Nadaf, Sameer J.. 2014. Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form. Advances in Chemistry،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-448214
Modern Language Association (MLA)
Jadhav, Namdeo R.…[et al.]. Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form. Advances in Chemistry No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-448214
American Medical Association (AMA)
Jadhav, Namdeo R.& Kambar, Ramesh S.& Nadaf, Sameer J.. Dual Wavelength Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Felodipine from Tablet Dosage Form. Advances in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-448214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448214