![](/images/graphics-bg.png)
Oxidative Stress in Alzheimer's and Parkinson's Diseases : Insights from the Yeast Saccharomyces cerevisiae
Joint Authors
Batista-Nascimento, Liliana
Menezes, Regina A.
Rodrigues-Pousada, Claudina
Pimentel, Catarina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Alzheimer's (AD) and Parkinson's (PD) diseases are the two most common causes of dementia in aged population.
Both are protein-misfolding diseases characterized by the presence of protein deposits in the brain.
Despite growing evidence suggesting that oxidative stress is critical to neuronal death, its precise role in disease etiology and progression has not yet been fully understood.
Budding yeast Saccharomyces cerevisiae shares conserved biological processes with all eukaryotic cells, including neurons.
This fact together with the possibility of simple and quick genetic manipulation highlights this organism as a valuable tool to unravel complex and fundamental mechanisms underlying neurodegeneration.
In this paper, we summarize the latest knowledge on the role of oxidative stress in neurodegenerative disorders, with emphasis on AD and PD.
Additionally, we provide an overview of the work undertaken to study AD and PD in yeast, focusing the use of this model to understand the effect of oxidative stress in both diseases.
American Psychological Association (APA)
Pimentel, Catarina& Batista-Nascimento, Liliana& Rodrigues-Pousada, Claudina& Menezes, Regina A.. 2012. Oxidative Stress in Alzheimer's and Parkinson's Diseases : Insights from the Yeast Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448234
Modern Language Association (MLA)
Pimentel, Catarina…[et al.]. Oxidative Stress in Alzheimer's and Parkinson's Diseases : Insights from the Yeast Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-448234
American Medical Association (AMA)
Pimentel, Catarina& Batista-Nascimento, Liliana& Rodrigues-Pousada, Claudina& Menezes, Regina A.. Oxidative Stress in Alzheimer's and Parkinson's Diseases : Insights from the Yeast Saccharomyces cerevisiae. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-448234
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448234