Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique
Joint Authors
Gallarate, Marina
Battaglia, Luigi
Peira, E.
Trotta, Michele
Source
International Journal of Chemical Engineering
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Engineering Sciences and Information Technology
Abstract EN
Stearic acid solid lipid nanoparticles were prepared according to a new technique, called coacervation.
The main goal of this experimental work was the entrapment of peptide drugs into SLN, which is a difficult task, since their chemical characteristics (molecular weight, hydrophilicity, and stability) hamper peptide-containing formulations.
Insulin and leuprolide, chosen as model peptide drugs, were encapsulated within nanoparticles after hydrophobic ion pairing with anionic surfactants.
Peptide integrity was maintained after encapsulation, and nanoparticles can act in vitro as a sustained release system for peptide.
American Psychological Association (APA)
Gallarate, Marina& Battaglia, Luigi& Peira, E.& Trotta, Michele. 2011. Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique. International Journal of Chemical Engineering،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-448258
Modern Language Association (MLA)
Gallarate, Marina…[et al.]. Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique. International Journal of Chemical Engineering No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-448258
American Medical Association (AMA)
Gallarate, Marina& Battaglia, Luigi& Peira, E.& Trotta, Michele. Peptide-Loaded Solid Lipid Nanoparticles Prepared through Coacervation Technique. International Journal of Chemical Engineering. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-448258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448258