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A Single Dose of Oral BCG Moreau Fails to Boost Systemic IFN-γ Responses to Tuberculin in Children in the Rural Tropics : Evidence for a Barrier to Mucosal Immunization
Joint Authors
Castello-Branco, Luiz R.
Chico, Martha E.
Lewis, David J.
Moncayo, Ana-Lucia
Cooper, Philip J.
Cosgrove, Catherine A.
Vaca, Maritza
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Immune responses to oral vaccines are impaired in populations living in conditions of poverty in developing countries, and there is evidence that concurrent geohelminth infections may contribute to this effect.
We vaccinated 48 children living in rural communities in Ecuador with a single oral dose of 100 mg of BCG Moreau RDJ and measured the frequencies of tuberculin-stimulated peripheral blood mononuclear cells expressing IFN-γ before and after vaccination.
Vaccinated children had active ascariasis (n=20) or had been infected but received short- (n=13) or long-term (n=15) repeated treatments with albendazole prior to vaccination to treat ascariasis.
All children had a BCG scar from neonatal vaccination.
There was no evidence of a boosting of postvaccination IFN-γ responses in any of the 3 study groups.
Our data provide support for the presence of a barrier to oral vaccination among children from the rural tropics that appeared to be independent of concurrent ascariasis.
American Psychological Association (APA)
Vaca, Maritza& Moncayo, Ana-Lucia& Cosgrove, Catherine A.& Chico, Martha E.& Castello-Branco, Luiz R.& Lewis, David J.…[et al.]. 2012. A Single Dose of Oral BCG Moreau Fails to Boost Systemic IFN-γ Responses to Tuberculin in Children in the Rural Tropics : Evidence for a Barrier to Mucosal Immunization. Journal of Tropical Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-448273
Modern Language Association (MLA)
Vaca, Maritza…[et al.]. A Single Dose of Oral BCG Moreau Fails to Boost Systemic IFN-γ Responses to Tuberculin in Children in the Rural Tropics : Evidence for a Barrier to Mucosal Immunization. Journal of Tropical Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-448273
American Medical Association (AMA)
Vaca, Maritza& Moncayo, Ana-Lucia& Cosgrove, Catherine A.& Chico, Martha E.& Castello-Branco, Luiz R.& Lewis, David J.…[et al.]. A Single Dose of Oral BCG Moreau Fails to Boost Systemic IFN-γ Responses to Tuberculin in Children in the Rural Tropics : Evidence for a Barrier to Mucosal Immunization. Journal of Tropical Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-448273
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448273