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Metal Toxicity at the Synapse : Presynaptic, Postsynaptic, and Long-Term Effects
Joint Authors
Sadiq, Sanah
Chowdhury, Arnab
Ghazala, Zena
Büsselberg, Dietrich
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-42, 42 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
42
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Metal neurotoxicity is a global health concern.
This paper summarizes the evidence for metal interactions with synaptic transmission and synaptic plasticity.
Presynaptically metal ions modulate neurotransmitter release through their interaction with synaptic vesicles, ion channels, and the metabolism of neurotransmitters (NT).
Many metals (e.g., Pb2+, Cd2+, and Hg+) also interact with intracellular signaling pathways.
Postsynaptically, processes associated with the binding of NT to their receptors, activation of channels, and degradation of NT are altered by metals.
Zn2+, Pb2+, Cu2+, Cd2+, Ni2+, Co2+, Li3+, Hg+, and methylmercury modulate NMDA, AMPA/kainate, and/or GABA receptors activity.
Al3+, Pb2+, Cd2+, and As2O3 also impair synaptic plasticity by targeting molecules such as CaM, PKC, and NOS as well as the transcription machinery involved in the maintenance of synaptic plasticity.
The multiple effects of metals might occur simultaneously and are based on the specific metal species, metal concentrations, and the types of neurons involved.
American Psychological Association (APA)
Sadiq, Sanah& Ghazala, Zena& Chowdhury, Arnab& Büsselberg, Dietrich. 2012. Metal Toxicity at the Synapse : Presynaptic, Postsynaptic, and Long-Term Effects. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-42.
https://search.emarefa.net/detail/BIM-448284
Modern Language Association (MLA)
Sadiq, Sanah…[et al.]. Metal Toxicity at the Synapse : Presynaptic, Postsynaptic, and Long-Term Effects. Journal of Toxicology No. 2012 (2012), pp.1-42.
https://search.emarefa.net/detail/BIM-448284
American Medical Association (AMA)
Sadiq, Sanah& Ghazala, Zena& Chowdhury, Arnab& Büsselberg, Dietrich. Metal Toxicity at the Synapse : Presynaptic, Postsynaptic, and Long-Term Effects. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-42.
https://search.emarefa.net/detail/BIM-448284
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448284