Multifocal and Multicentric Glioblastoma with Leptomeningeal Gliomatosis : A Case Report and Review of the Literature
Joint Authors
Merrell, Ryan T.
Bit-Ivan, Esther
Farhat, Hamad I.
Shakur, Sophia F.
Watkin, William G.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Glioblastoma (GBM) rarely presents as an infratentorial tumor in adults.
The authors present a case of concomitant supratentorial and infratentorial GBM in an adult.
A 72-year-old man presented with headache, nausea, vomiting, and lightheadedness.
Initial MR images revealed enhancing masses in the right cerebellum and right posterior periventricular region.
The patient underwent a suboccipital craniotomy and resection of the cerebellar lesion.
Final histopathology was consistent with glioblastoma.
The patient went on to receive standard radiation treatment for GBM with concurrent and adjuvant temozolomide.
However, the patient experienced clinical deterioration within a few days after starting radiotherapy.
He and his family decided to forego treatment and pursue palliative care.
The patient expired three months after the initial diagnosis.
Autopsy findings supported the diagnosis of GBM with leptomeningeal gliomatosis and involvement of the cerebrum, cerebellum, and spinal cord.
The authors review the literature and propose that the pathogenesis of multiple and multicentric GBM may involve neural stem cells within the subventricular zone or could result from tumor dissemination along established CNS routes, such as white matter tracts and CSF pathways.
American Psychological Association (APA)
Shakur, Sophia F.& Bit-Ivan, Esther& Watkin, William G.& Merrell, Ryan T.& Farhat, Hamad I.. 2013. Multifocal and Multicentric Glioblastoma with Leptomeningeal Gliomatosis : A Case Report and Review of the Literature. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448286
Modern Language Association (MLA)
Shakur, Sophia F.…[et al.]. Multifocal and Multicentric Glioblastoma with Leptomeningeal Gliomatosis : A Case Report and Review of the Literature. Case Reports in Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448286
American Medical Association (AMA)
Shakur, Sophia F.& Bit-Ivan, Esther& Watkin, William G.& Merrell, Ryan T.& Farhat, Hamad I.. Multifocal and Multicentric Glioblastoma with Leptomeningeal Gliomatosis : A Case Report and Review of the Literature. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448286