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Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism : Special Considerations on Ovarian Cancer
Joint Authors
Kim, Tae Hun
Suh, Dong Hoon
Song, Yong-Sang
Kim, Mi-Kyung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ovarian cancer is the most lethal gynecologic malignancy among women worldwide and is presumed to result from the presence of ovarian cancer stem cells.
To overcome the limitation of current anticancer agents, another anticancer strategy is necessary to effectively target cancer stem cells in ovarian cancer.
In many types of malignancies, including ovarian cancer, metformin, one of the most popular antidiabetic drugs, has been demonstrated to exhibit chemopreventive and anticancer efficacy with respect to incidence and overall survival rates.
Thus, the metabolic reprogramming of cancer and cancer stem cells driven by genetic alterations during carcinogenesis and cancer progression could be therapeutically targeted.
In this review, the potential efficacy and anticancer mechanisms of metformin against ovarian cancer stem cells will be discussed.
American Psychological Association (APA)
Kim, Tae Hun& Suh, Dong Hoon& Kim, Mi-Kyung& Song, Yong-Sang. 2014. Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism : Special Considerations on Ovarian Cancer. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448290
Modern Language Association (MLA)
Kim, Tae Hun…[et al.]. Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism : Special Considerations on Ovarian Cancer. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-448290
American Medical Association (AMA)
Kim, Tae Hun& Suh, Dong Hoon& Kim, Mi-Kyung& Song, Yong-Sang. Metformin against Cancer Stem Cells through the Modulation of Energy Metabolism : Special Considerations on Ovarian Cancer. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-448290
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448290