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Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy
Joint Authors
Soliman, Hany
Mah, Katherine
Caldwell, Curtis B.
Poon, Ian
Sattarivand, Mike
Source
International Journal of Molecular Imaging
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Quantitative PET response assessment during therapy requires regions of interest (ROI).
Commonly, a fixed-size ROI is placed at the maximum uptake point in the pretreatment study.
For intratreatment, the ROI is placed either at the maximum uptake point (ROIpeak) or at the same location as the pretreatment ROI (ROIsame).
We have evaluated the effects of the ROI placement on response assessment.
Methods.
PET scans of 15 head and neck cancer patients were used to evaluate the effects of the two ROI methods on response assessment.
Results.
The average intratreatment ROIpeak uptake was 13.4% higher than the ROIsame uptake (range −14% to 38%).
The average relative change in ROIpeak uptake was 7.9% lower than ROIsame uptake (range −5% to 36%), resulting in ambiguous tumour classification in 19% of the tumours.
Conclusion.
Quantitative PET response assessment using a fixed-size ROI is sensitive the ROI placement.
The difference between ROIpeak and ROIsame could be substantial resulting in ambiguous response assessment.
Although the fixed-size ROI is simple to implement, it is also prone to the limitations and should be used with caution.
Clinical trial data are necessary to establish reliable thresholds for fixed-size ROI techniques and to evaluate their efficacy for response assessment.
American Psychological Association (APA)
Sattarivand, Mike& Caldwell, Curtis B.& Poon, Ian& Soliman, Hany& Mah, Katherine. 2013. Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy. International Journal of Molecular Imaging،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448298
Modern Language Association (MLA)
Sattarivand, Mike…[et al.]. Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy. International Journal of Molecular Imaging No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-448298
American Medical Association (AMA)
Sattarivand, Mike& Caldwell, Curtis B.& Poon, Ian& Soliman, Hany& Mah, Katherine. Effects of ROI Placement on PET-Based Assessment of Tumor Response to Therapy. International Journal of Molecular Imaging. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448298