A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia
Joint Authors
Na, Songqing
Schmidt, Clint
Nagpal, Sunil
Zhao, Jingyong
Chandrasekhar, Srinivasan
Ma, Yanfei
Zeng, Qing Q.
Chin, William W.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Vitamin D receptor (VDR) agonists are currently the agents of choice for the treatment of psoriasis, a skin inflammatory indication that is believed to involve an autoimmune component.
1,25-dihydroxyvitamin D3 [1,25-(OH)2D3], the biologically active metabolite of vitamin D, has shown efficacy in animal autoimmune disease models of multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and type I diabetes.
However, the side effect of 1,25-(OH)2D3 and its synthetic secosteroidal analogs is hypercalcemia, which is a major impediment in their clinical development for autoimmune diseases.
Hypercalcemia develops as a result of the action of VDR agonists on the intestine.
Here, we describe the identification of a VDR modulator (VDRM) compound A that was transcriptionally less active in intestinal cells and as a result exhibited less calcemic activity in vivo than 1,25-(OH)2D3.
Cytokine analysis indicated that the VDRM not only modulated the T-helper cell balance from Th1 to Th2 effector function but also inhibited Th17 differentiation.
Finally, we demonstrate that the oral administration of compound A inhibited the induction and progress of experimental autoimmune encephalomyelitis in mice without causing hypercalcemia.
American Psychological Association (APA)
Na, Songqing& Ma, Yanfei& Zhao, Jingyong& Schmidt, Clint& Zeng, Qing Q.& Chandrasekhar, Srinivasan…[et al.]. 2011. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-448313
Modern Language Association (MLA)
Na, Songqing…[et al.]. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Diseases No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-448313
American Medical Association (AMA)
Na, Songqing& Ma, Yanfei& Zhao, Jingyong& Schmidt, Clint& Zeng, Qing Q.& Chandrasekhar, Srinivasan…[et al.]. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-448313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448313