PPARs Mediate Lipid Signaling in Inflammation and Cancer
Joint Authors
Michalik, Liliane
Wahli, Walter
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-21
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Lipid mediators can trigger physiological responses by activating nuclear hormone receptors, such as the peroxisome proliferator-activated receptors (PPARs).
PPARs, in turn, control the expression of networks of genes encoding proteins involved in all aspects of lipid metabolism.
In addition, PPARs are tumor growth modifiers, via the regulation of cancer cell apoptosis, proliferation, and differentiation, and through their action on the tumor cell environment, namely, angiogenesis, inflammation, and immune cell functions.
Epidemiological studies have established that tumor progression may be exacerbated by chronic inflammation.
Here, we describe the production of the lipids that act as activators of PPARs, and we review the roles of these receptors in inflammation and cancer.
Finally, we consider emerging strategies for therapeutic intervention.
American Psychological Association (APA)
Michalik, Liliane& Wahli, Walter. 2008. PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-15.
https://search.emarefa.net/detail/BIM-448325
Modern Language Association (MLA)
Michalik, Liliane& Wahli, Walter. PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Research No. 2008 (2008), pp.1-15.
https://search.emarefa.net/detail/BIM-448325
American Medical Association (AMA)
Michalik, Liliane& Wahli, Walter. PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-15.
https://search.emarefa.net/detail/BIM-448325
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448325