Etanercept-Induced Myelopathy in a Pediatric Case of Blau Syndrome
Joint Authors
Caracseghi, Fabiola
Melendo-Perez, Susana
Sanchez-Montanez, Angel
Modesto, Consuelo
Roig-Quilis, Manuel
Izquierdo-Blasco, Jaume
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Blau syndrome is a rare autoinflammatory disorder within the group of pediatric granulomatous diseases.
Mutations in nucleotide-binding oligomerization domain 2 (NOD2/CARD15) are responsible for this condition, which has an autosomal dominant pattern of inheritance and variable expressivity.
The clinical picture includes arthritis, uveitis, skin rash, and granulomatous inflammation.
Central nervous system involvement is seldom reported, although some isolated cases of seizures, neurosensorial hearing loss, and transient cranial nerve palsy have been described.
Treatment consists of nonsteroidal anti-inflammatory drugs, corticosteroids, and immunosuppressive agents, among which anti-tumor-necrosis-factor-alpha (TNF-α) biologic agents, such as etanercept, play an important role.
Among the major adverse effects of TNF-α inhibitors, demyelinating disease, multiple sclerosis, and acute transverse myelitis have been reported in adults.
We describe a case of pediatric Blau syndrome affected by etanercept-induced myelopathy, manifesting as a clinical syndrome of transverse myelitis.
The patient experienced rapid recovery after etanercept was discontinued.
To our knowledge, this is the first such case reported in the literature and, possibly, the one with the latest onset, following 8 years of treatment.
We discuss the etiopathogenic mechanisms of this reaction and possible explanations for the imaging findings.
American Psychological Association (APA)
Caracseghi, Fabiola& Izquierdo-Blasco, Jaume& Sanchez-Montanez, Angel& Melendo-Perez, Susana& Roig-Quilis, Manuel& Modesto, Consuelo. 2012. Etanercept-Induced Myelopathy in a Pediatric Case of Blau Syndrome. Case Reports in Rheumatology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-448332
Modern Language Association (MLA)
Caracseghi, Fabiola…[et al.]. Etanercept-Induced Myelopathy in a Pediatric Case of Blau Syndrome. Case Reports in Rheumatology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-448332
American Medical Association (AMA)
Caracseghi, Fabiola& Izquierdo-Blasco, Jaume& Sanchez-Montanez, Angel& Melendo-Perez, Susana& Roig-Quilis, Manuel& Modesto, Consuelo. Etanercept-Induced Myelopathy in a Pediatric Case of Blau Syndrome. Case Reports in Rheumatology. 2012. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-448332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448332