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Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats
Joint Authors
Popa, Cristina Liana
Ciobanu, Carmen Steluta
Predoi, Daniela
Prodan, Alina Mihaela
Iconaru, Simona Liliana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Iron oxide-silica nanoparticles (IOSi-NPs) were prepared from a mixture of ferrous chloride tetrahydrate and ferric chloride hexahydrate dropped into a silica xerogel composite.
The structure and morphology of the synthesized maghemite nanoparticles into the silica xerogel were analysed by X-ray diffraction measurements, scanning electron microscopy equipped with an energy dispersive X-ray spectrometer, and transmission electron microscopy.
The results of the EDAX analysis indicated that the embedded particles were iron oxide nanoparticles.
The particle size of IOSi-NPs calculated from the XRD analysis was estimated at around 12.5 nm.
The average size deduced from the particle size distribution is 13.7 ± 0.6 nm, which is in good agreement with XRD analysis.
The biocompatibility of IOSi-NPs was assessed by cell viability and cytoskeleton analysis.
Histopathology analysis was performed after 24 hours and 7 days, respectively, from the intratracheal instillation of a solution containing 0.5, 2.5, or 5 mg/kg IOSi-NPs.
The pathological micrographs of lungs derived from rats collected after the intratracheal instillation with a solution containing 0.5 mg/kg and 2.5 mg/kg IOSi-NPs show that the lung has preserved the architecture of the control specimen with no significant differences.
However, even at concentrations of 5 mg/kg, the effect of IOSi-NPS on the lungs was markedly reduced at 7 days posttreatment.
American Psychological Association (APA)
Prodan, Alina Mihaela& Ciobanu, Carmen Steluta& Popa, Cristina Liana& Iconaru, Simona Liliana& Predoi, Daniela. 2014. Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-448352
Modern Language Association (MLA)
Prodan, Alina Mihaela…[et al.]. Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-448352
American Medical Association (AMA)
Prodan, Alina Mihaela& Ciobanu, Carmen Steluta& Popa, Cristina Liana& Iconaru, Simona Liliana& Predoi, Daniela. Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-448352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448352