Chemotherapeutic Efficacy of Indigofera aspalathoides on 20-Methylcholanthrene-Induced Fibrosarcoma in Rats
Joint Authors
Sivagnanam, Selva Kumar
Balasubramanian, Maruthaiveeran Periyasamy
Rao, Mudiganti Ram Krishna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The present study was undertaken to test the chemopreventive effects of one herbal medicinal plant, Indigofera aspalathoides, on chemically induced carcinogenesis in rats.
A well-known polyaromatic hydrocarbon, namely, 20-methylcholanthrene, which is a known carcinogenic substance, was used to induce fibrosarcoma in Wistar strain of male albino rats.
Fibrosarcoma rats were treated with aqueous extracts of Indigofera aspalathoides.
The rats were divided into four groups, each consisting of six animals.
Group I served as normal control, Group II served as fibrosarcoma-induced animals, Group III were fibrosarcoma-bearing animals treated with aqueous extracts of Indigofera aspalathoides, and Group IV animals, which were normal healthy animals treated with Indigofera aspalathoides aqueous extract, served as drug control set.
Group III and Group IV animals were treated with aqueous extract of Indigofera aspalathoides intraperitoneally at a dose of 250 mg/kg.
b.w.
for 30 days.
The fibrosarcoma was proved by pathological examinations.
The activity levels of nucleic acids such as total DNA and RNA and hexose, hexosamine, and sialic acid in liver and kidney of treated rats were used to monitor the chemopreventive role of the plant extract.
The observed increase in the levels of DNA, RNA, hexose, hexosamine, and sialic acid in liver and kidney tissues of fibrosarcoma-bearing animals reached near normal state after the treatment with aqueous extracts of Indigofera aspalathoides, suggesting that Indigofera aspalathoides does have a chemotherapeutic role.
American Psychological Association (APA)
Sivagnanam, Selva Kumar& Rao, Mudiganti Ram Krishna& Balasubramanian, Maruthaiveeran Periyasamy. 2012. Chemotherapeutic Efficacy of Indigofera aspalathoides on 20-Methylcholanthrene-Induced Fibrosarcoma in Rats. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448359
Modern Language Association (MLA)
Sivagnanam, Selva Kumar…[et al.]. Chemotherapeutic Efficacy of Indigofera aspalathoides on 20-Methylcholanthrene-Induced Fibrosarcoma in Rats. ISRN Pharmacology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-448359
American Medical Association (AMA)
Sivagnanam, Selva Kumar& Rao, Mudiganti Ram Krishna& Balasubramanian, Maruthaiveeran Periyasamy. Chemotherapeutic Efficacy of Indigofera aspalathoides on 20-Methylcholanthrene-Induced Fibrosarcoma in Rats. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448359