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The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice
Joint Authors
Hayashi, Michio
Tojo, Akihiro
Shimosawa, Tatsuo
Fujita, Toshiro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Adrenomedullin has an antioxidative action and protects organs in various diseases.
To clarify the role of adrenomedullin in diabetic nephropathy, we investigated the NADPH oxidase expression, renin-secreting granular cell (GC) hyperplasia, and glomerular matrix expansion in the streptozotocin (STZ)-induced diabetic adrenomedullin gene knockout (AMKO) mice compared with the STZ-diabetic wild mice at 10 weeks.
The NADPH oxidase p47phox expression and lipid peroxidation products were enhanced in the glomeruli of the diabetic mice compared with that observed in the controls in both wild and AMKO mice.
These changes were more obvious in the AMKO mice than in the wild mice.
Glomerular mesangial matrix expansion was more severe in the diabetic AMKO mice than in the diabetic wild mice and exhibited a positive correlation with the degree of lipid peroxidation products in the glomeruli.
Proteinuria was significantly higher in the diabetic AMKO mice than in the diabetic wild mice.
The GC hyperplasia score and the renal prorenin expression were significantly increased in the diabetic AMKO mice than in the diabetic wild mice, and a positive correlation was observed with the NADPH oxidase expression in the macula densa.
The endogenous adrenomedullin gene exhibits an antioxidant action via the inhibition of NADPH oxidase probably by suppressing the local renin-angiotensin system.
American Psychological Association (APA)
Hayashi, Michio& Tojo, Akihiro& Shimosawa, Tatsuo& Fujita, Toshiro. 2013. The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448363
Modern Language Association (MLA)
Hayashi, Michio…[et al.]. The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice. Journal of Diabetes Research No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448363
American Medical Association (AMA)
Hayashi, Michio& Tojo, Akihiro& Shimosawa, Tatsuo& Fujita, Toshiro. The Role of Adrenomedullin in the Renal NADPH Oxidase and (Pro)renin in Diabetic Mice. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448363