Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice
Joint Authors
Chen, Yi-Hung
Ivanic, Boris
Chuang, Chieh-Min
Lin, Jaung Geng
Lu, Dah-Yuu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-17
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The aims of this study were to characterize the protective profile of electroacupuncture (EA) on cocaine-induced seizures and mortality in mice.
Mice were treated with EA (2 Hz, 50 Hz, and 100 Hz), or they underwent needle insertion without anesthesia at the Dazhui (GV14) and Baihui (GV20) acupoints before cocaine administration.
EA at 50 Hz applied to GV14 and GV20 significantly reduced the seizure severity induced by a single dose of cocaine (75 mg/kg; i.p.).
Furthermore, needle insertion into GV14 and GV20 and EA at 2 Hz and 50 Hz at both acupoints significantly reduced the mortality rate induced by a single lethal dose of cocaine (125 mg/kg; i.p.).
In the sham control group, EA at 50 Hz applied to bilateral Tianzong (SI11) acupoints had no protective effects against cocaine.
In addition, EA at 50 Hz applied to GV14 and GV20 failed to reduce the incidence of seizures and mortality induced by the local anesthetic procaine.
In an immunohistochemistry study, EA (50 Hz) pretreatment at GV14 and GV20 decreased cocaine (75 mg/kg; i.p.)-induced c-Fos expression in the paraventricular thalamus.
While the dopamine D3 receptor antagonist, SB-277011-A (30 mg/kg; s.c), did not by itself affect cocaine-induced seizure severity, it prevented the effects of EA on cocaine-induced seizures.
These results suggest that EA alleviates cocaine-induced seizures and mortality and that the dopamine D3 receptor is involved, at least in part, in the anticonvulsant effects of EA in mice.
American Psychological Association (APA)
Chen, Yi-Hung& Ivanic, Boris& Chuang, Chieh-Min& Lu, Dah-Yuu& Lin, Jaung Geng. 2013. Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-448384
Modern Language Association (MLA)
Chen, Yi-Hung…[et al.]. Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-448384
American Medical Association (AMA)
Chen, Yi-Hung& Ivanic, Boris& Chuang, Chieh-Min& Lu, Dah-Yuu& Lin, Jaung Geng. Electroacupuncture Reduces Cocaine-Induced Seizures and Mortality in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-448384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448384