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Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF
Joint Authors
Zhu, HuiFeng
Xue, LiJun
Wan, Dong
Luo, Yong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the role and mechanism of catalpol on neuroprotective effects and memory enhancing effects simultaneously, neuroprotective effects of catalpol were assessed by neurological deficits score, TTC staining, and cerebral blood flow detecting.
Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central cholinergic system and BDNF.
Edaravone and oxiracetam were used for positive control drugs based on its different action.
Results showed that catalpol and edaravone significantly facilitated neurological function recovery, reduced infarction volume, and increased cerebral blood flow in stroke mice.
Catalpol and oxiracetam decreased the escape latency significantly and increased the numbers of crossing platform obviously.
The levels of ACh, ChAT, and BDNF in catalpol group were increased in a dose-dependent manner, and AChE declined with a U-shaped dose-response curve.
Moreover, the levels of muscarinic AChR subtypes M1 and M2 in hippocampus were considerably raised by catalpol.
These results demonstrated that catalpol may be useful for neuroprotection and memory enhancement, and the mechanism may be related to the central cholinergic system.
American Psychological Association (APA)
Wan, Dong& Xue, LiJun& Zhu, HuiFeng& Luo, Yong. 2013. Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448413
Modern Language Association (MLA)
Wan, Dong…[et al.]. Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-448413
American Medical Association (AMA)
Wan, Dong& Xue, LiJun& Zhu, HuiFeng& Luo, Yong. Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448413