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Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis
Joint Authors
Bahat Özdoğan, Elif
Özdemir, Tuğba
Doğan, İsmail
Çobanoğlu, Ümit
İmamoğlu, Mustafa
Arslansoyu Çamlar, Seçil
Tosun, İlknur
Sönmez, Bircan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
This study aimed to demonstrate if the addition of anti-inflammatory treatment to antibiotic therapy shows any superiority to the treatment with antibiotic only.
Methods.
Forty-nine Wistar rats were divided into 7 groups.
Pyelonephritis was performed by E.
coli injection to upper pole of kidneys except control group.
Group 2 was not treated.
Ceftriaxone, ketoprofen, “ceftriaxone + ketoprofen,” methylprednisolone, and “ceftriaxone + methylprednisolone” were given in the groups.
The technetium-99m-dimercaptosuccinic acid scintigraphies were performed in 3rd day to detect pyelonephritis and 10th week to detect renal scarring.
All kidneys were also histopathologically evaluated.
Results.
When 3rd day and 10th week scintigraphies were compared, initial 2.00 ± 0.30 point pyelonephritis score resulted in 0.71 ± 0.36 renal scar score in “ceftriaxone + ketoprofen” group (P=0.039).
Initial 2.00 ± 0.43 point pyelonephritis score resulted in 0.86 ± 0.26 renal scar score in “ceftriaxone + methylprednisolone” group (P=0.041).
Renal scar score was declined in “ceftriaxone + ketoprofen” group and “ceftriaxone + methylprednisolone” group compared with no-treatment group on 10th week of the study (P=0.026, P=0.044).
On histopathological evaluation, it was seen that renal scar prevalence and expansion declined significantly in “ceftriaxone + ketoprofen and ceftriaxone + methylprednisolone” (P=0.011, P=0.023).
Conclusion.
It was evidenced that ceftriaxone treatment in combination with ketoprofen or methylprednisolone declined scar formation in scintigraphic and histopathologic examinations of the kidneys.
American Psychological Association (APA)
Bahat Özdoğan, Elif& Özdemir, Tuğba& Arslansoyu Çamlar, Seçil& İmamoğlu, Mustafa& Çobanoğlu, Ümit& Sönmez, Bircan…[et al.]. 2014. Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448423
Modern Language Association (MLA)
Bahat Özdoğan, Elif…[et al.]. Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-448423
American Medical Association (AMA)
Bahat Özdoğan, Elif& Özdemir, Tuğba& Arslansoyu Çamlar, Seçil& İmamoğlu, Mustafa& Çobanoğlu, Ümit& Sönmez, Bircan…[et al.]. Could Pyelonephritic Scarring Be Prevented by Anti-Inflammatory Treatment? An Experimental Model of Acute Pyelonephritis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448423