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Circuit Models and Experimental Noise Measurements of Micropipette Amplifiers for Extracellular Neural Recordings from Live Animals
Joint Authors
Chen, Chang Hao
Mak, Peng Un
Klug, Achim
Vai, Mang I
Lei, Tim C.
Pun, Sio Hang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Glass micropipettes are widely used to record neural activity from single neurons or clusters of neurons extracellularly in live animals.
However, to date, there has been no comprehensive study of noise in extracellular recordings with glass micropipettes.
The purpose of this work was to assess various noise sources that affect extracellular recordings and to create model systems in which novel micropipette neural amplifier designs can be tested.
An equivalent circuit of the glass micropipette and the noise model of this circuit, which accurately describe the various noise sources involved in extracellular recordings, have been developed.
Measurement schemes using dead brain tissue as well as extracellular recordings from neurons in the inferior colliculus, an auditory brain nucleus of an anesthetized gerbil, were used to characterize noise performance and amplification efficacy of the proposed micropipette neural amplifier.
According to our model, the major noise sources which influence the signal to noise ratio are the intrinsic noise of the neural amplifier and the thermal noise from distributed pipette resistance.
These two types of noise were calculated and measured and were shown to be the dominating sources of background noise for in vivo experiments.
American Psychological Association (APA)
Chen, Chang Hao& Pun, Sio Hang& Mak, Peng Un& Vai, Mang I& Klug, Achim& Lei, Tim C.. 2014. Circuit Models and Experimental Noise Measurements of Micropipette Amplifiers for Extracellular Neural Recordings from Live Animals. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-448431
Modern Language Association (MLA)
Chen, Chang Hao…[et al.]. Circuit Models and Experimental Noise Measurements of Micropipette Amplifiers for Extracellular Neural Recordings from Live Animals. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-448431
American Medical Association (AMA)
Chen, Chang Hao& Pun, Sio Hang& Mak, Peng Un& Vai, Mang I& Klug, Achim& Lei, Tim C.. Circuit Models and Experimental Noise Measurements of Micropipette Amplifiers for Extracellular Neural Recordings from Live Animals. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-448431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448431