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Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis
Joint Authors
Zhang, Eryong
Zhang, Jianmin
Guo, Yingqiang
Meng, Wei
Shi, Yingkang
Yu, Fengxu
Chen, Huaiqing
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Previous research has observed concentration polarization in LDL and HDL in the arterial system.
However, there is no report that links this concentration polarization to the development of vascular atherosclerosis (AS).
Therefore, the purpose of this study is to establish the relationship between concentration difference of LDL and HDL and shear stress using a carotid bifurcation vascular model.
PTFE was employed to create the carotid bifurcation model.
Endothelial cells were coated on the inner wall of the graft.
In a recirculation system, HDL and LDL concentration were measured under two different ICA flow velocities at 5 different locations within our model.
We report the following: (1) LDL and HDL concentration difference was observed in both high flow and low flow environments; (2) the degree of LDL and HDL concentration polarization varied depending of high flow and low flow environment; (3) absolute values of concentration difference between LDL and HDL at the inner wall surface decreased with the increase in shear stress when shear stress was more than 1.5 Pa.
This variation trend would be more pronounced if shear stress were less than 0.5 Pa.
Our study suggests that under the action of shear stress, concentration differences of LDL or HDL create a disturbance in the balance of atherogenic factors and anti-As factors, resulting in the occurrence of AS.
American Psychological Association (APA)
Meng, Wei& Yu, Fengxu& Chen, Huaiqing& Zhang, Jianmin& Zhang, Eryong& Guo, Yingqiang…[et al.]. 2012. Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448466
Modern Language Association (MLA)
Meng, Wei…[et al.]. Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-448466
American Medical Association (AMA)
Meng, Wei& Yu, Fengxu& Chen, Huaiqing& Zhang, Jianmin& Zhang, Eryong& Guo, Yingqiang…[et al.]. Relationship between Concentration Difference of Different Density Lipoproteins and Shear Stress in Atherosclerosis. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-448466
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448466