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Clinical Effects of a Natural Extract of Urinary Human Menopausal Gonadotrophin in Normogonadotropic Infertile Patients
Joint Authors
Source
International Journal of Reproductive Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-24
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Purified human menopausal gonadotropin (HMG) is a natural product extracted from the urine of postmenopausal women that contains pituitary follicle-stimulating hormone (FSH), luteinizing hormone (LH), and a small amount of human chorionic gonadotropin (HCG).
Here we retrospectively conducted a clinical pharmaceutical study on a cohort of normogonadotropic infertile patients addressed to long GnRH-agonist protocol with serum LH concentration ranging from 0.5 IU/L to 1.5 IU/L during the midfollicle phase, aiming at evaluating the effects of purified HMG supplementation during ovarian stimulation.
There was no significant difference in either the basic clinical features of the patients or the pregnancy rate (71.4% versus 66.3%, P>0.05) or other related indicators of pregnancy outcome.
However, there was a higher level of serum oestradiol (E2) on the day of human chorionic gonadotropin (HCG) (1999.10±860.50 IU/L versus 2883.29±1427.382 IU/L, P=0.000) but lower fertilization rate (89.1% versus 69.6%, P<0.000) in patients getting HMG supplementation and a higher risk of developing ovarian hyperstimulation syndrome (OHSS).
We suppose that exogenous LH supplementation is not needed when serum LH concentration of the midfollicle phase is around 0.5–1.5 IU/L during the long GnRH-agonist protocol.
Adding exogenous HMG may decrease the fertilization rate and increase the risk of developing OHSS.
American Psychological Association (APA)
Hua, Rui& Ma, Lan& Li, Hong. 2013. Clinical Effects of a Natural Extract of Urinary Human Menopausal Gonadotrophin in Normogonadotropic Infertile Patients. International Journal of Reproductive Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-448467
Modern Language Association (MLA)
Hua, Rui…[et al.]. Clinical Effects of a Natural Extract of Urinary Human Menopausal Gonadotrophin in Normogonadotropic Infertile Patients. International Journal of Reproductive Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-448467
American Medical Association (AMA)
Hua, Rui& Ma, Lan& Li, Hong. Clinical Effects of a Natural Extract of Urinary Human Menopausal Gonadotrophin in Normogonadotropic Infertile Patients. International Journal of Reproductive Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-448467
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448467