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Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors
Joint Authors
Mostafa Kamel, Yasser
Kirchner, Jennifer
Messam, Conrad
Martin, Anne-Marie
Baker, Katherine
Pandite, Lini
Pillarisetti, Kodandaram
Erickson-Miller, Connie L.
Gibbard, Anna
Liu, Yuan
Chadderton, Antony
El-Hariry, Iman
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Thrombopoietin (TPO) receptor agonists represent a new approach for the treatment of thrombocytopenia, which may develop as a consequence of immune thrombocytopenia, chemotherapy treatment, chronic hepatitis C infection, or myelodysplastic syndromes.
There are concerns that use of certain growth factors can hasten disease progression in some types of hematologic malignancies and solid tumors.
In this study, expression of MPL (TPO-R) mRNA was examined in tumor cell lines, patient tumor samples (renal cell carcinoma, prostatic carcinoma, soft tissue and bony/cartilage sarcoma, colon cancer, and lymphoma), and normal tissues using microarray analysis and qRT-PCR.
MPL mRNA is expressed at very low or undetectable levels compared with erythropoietin receptor (EPOR), human epidermal growth factor (ERBB2; HER2), and insulin-like growth factor-1 receptor (IGF1R) in these patient samples.
These data suggest TPO-R agonists will likely preferentially stimulate proliferation and differentiation of cells of megakaryocytic lineage, potentially demonstrating their utility for correcting thrombocytopenia in clinical settings.
American Psychological Association (APA)
Erickson-Miller, Connie L.& Chadderton, Antony& Gibbard, Anna& Kirchner, Jennifer& Pillarisetti, Kodandaram& Baker, Katherine…[et al.]. 2010. Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors. Journal of Oncology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-448476
Modern Language Association (MLA)
Erickson-Miller, Connie L.…[et al.]. Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors. Journal of Oncology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-448476
American Medical Association (AMA)
Erickson-Miller, Connie L.& Chadderton, Antony& Gibbard, Anna& Kirchner, Jennifer& Pillarisetti, Kodandaram& Baker, Katherine…[et al.]. Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-448476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448476