Glucose-6-Phosphate Dehydrogenase of Trypanosomatids : Characterization, Target Validation, and Drug Discovery
Joint Authors
Cordeiro, Artur T.
Igoillo-Esteve, Mariana
Michels, Paul A. M.
Gupta, Shreedhara
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In trypanosomatids, glucose-6-phosphate dehydrogenase (G6PDH), the first enzyme of the pentosephosphate pathway, is essential for the defense of the parasite against oxidative stress.
Trypanosoma brucei, Trypanosoma cruzi, and Leishmania mexicana G6PDHs have been characterized.
The parasites' G6PDHs contain a unique 37 amino acid long N-terminal extension that in T.
cruzi seems to regulate the enzyme activity in a redox-state-dependent manner.
T.
brucei and T.
cruzi G6PDHs, but not their Leishmania spp.
counterpart, are inhibited, in an uncompetitive way, by steroids such as dehydroepiandrosterone and derivatives.
The Trypanosoma enzymes are more susceptible to inhibition by these compounds than the human G6PDH.
The steroids also effectively kill cultured trypanosomes but not Leishmania and are presently considered as promising leads for the development of new parasite-selective chemotherapeutic agents.
American Psychological Association (APA)
Gupta, Shreedhara& Igoillo-Esteve, Mariana& Michels, Paul A. M.& Cordeiro, Artur T.. 2011. Glucose-6-Phosphate Dehydrogenase of Trypanosomatids : Characterization, Target Validation, and Drug Discovery. Molecular Biology International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-448500
Modern Language Association (MLA)
Gupta, Shreedhara…[et al.]. Glucose-6-Phosphate Dehydrogenase of Trypanosomatids : Characterization, Target Validation, and Drug Discovery. Molecular Biology International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-448500
American Medical Association (AMA)
Gupta, Shreedhara& Igoillo-Esteve, Mariana& Michels, Paul A. M.& Cordeiro, Artur T.. Glucose-6-Phosphate Dehydrogenase of Trypanosomatids : Characterization, Target Validation, and Drug Discovery. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-448500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448500