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The Brain Renin-Angiotensin System and Mitochondrial Function : Influence on Blood Pressure and Baroreflex in Transgenic Rat Strains
Joint Authors
Chappell, Mark C.
Diz, Debra I.
Arnold, Amy C.
Nautiyal, Manisha
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mitochondrial dysfunction is implicated in many cardiovascular diseases, including hypertension, and may be associated with an overactive renin-angiotensin system (RAS).
Angiotensin (Ang) II, a potent vasoconstrictor hormone of the RAS, also impairs baroreflex and mitochondrial function.
Most deleterious cardiovascular actions of Ang II are thought to be mediated by NADPH-oxidase- (NOX-) derived reactive oxygen species (ROS) that may also stimulate mitochondrial oxidant release and alter redox-sensitive signaling pathways in the brain.
Within the RAS, the actions of Ang II are counterbalanced by Ang-(1–7), a vasodilatory peptide known to mitigate against increased oxidant stress.
A balance between Ang II and Ang-(1–7) within the brain dorsal medulla contributes to maintenance of normal blood pressure and proper functioning of the arterial baroreceptor reflex for control of heart rate.
We propose that Ang-(1–7) may negatively regulate the redox signaling pathways activated by Ang II to maintain normal blood pressure, baroreflex, and mitochondrial function through attenuating ROS (NOX-generated and/or mitochondrial).
American Psychological Association (APA)
Nautiyal, Manisha& Arnold, Amy C.& Chappell, Mark C.& Diz, Debra I.. 2013. The Brain Renin-Angiotensin System and Mitochondrial Function : Influence on Blood Pressure and Baroreflex in Transgenic Rat Strains. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448529
Modern Language Association (MLA)
Nautiyal, Manisha…[et al.]. The Brain Renin-Angiotensin System and Mitochondrial Function : Influence on Blood Pressure and Baroreflex in Transgenic Rat Strains. International Journal of Hypertension No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448529
American Medical Association (AMA)
Nautiyal, Manisha& Arnold, Amy C.& Chappell, Mark C.& Diz, Debra I.. The Brain Renin-Angiotensin System and Mitochondrial Function : Influence on Blood Pressure and Baroreflex in Transgenic Rat Strains. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448529