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Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity : Effects of Cadmium, Mercury, and Copper
Joint Authors
Emelyanova, Larisa V.
Belyaeva, Elena A.
Sokolova, Tatyana V.
Zakharova, Irina O.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-24
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
To clarify the role of mitochondrial electron transport chain (mtETC) in heavy-metal-induced neurotoxicity, we studied action of Cd2+, Hg2+, and Cu2+ on cell viability, intracellular reactive oxygen species formation, respiratory function, and mitochondrial membrane potential of rat cell line PC12.
As found, the metals produced, although in a different way, dose- and time-dependent changes of all these parameters.
Importantly, Cd2+ beginning from 10 [mu]M and already at short incubation time (3 h) significantly inhibited the FCCP-uncoupled cell respiration; besides, practically the complete inhibition of the respiration was reached after 3 h incubation with 50 [mu]M Hg2+ or 500 [mu]M Cd2+, whereas even after 48 h exposure with 500 [mu]M Cu2+, only a 50% inhibition of the respiration occurred.
Against the Cd2+-induced cell injury, not only different antioxidants and mitochondrial permeability transition pore inhibitors were protective but also such mtETC effectors as FCCP and stigmatellin (complex III inhibitor).
However, all mtETC effectors used did not protect against the Hg2+- or Cu2+-induced cell damage.
Notably, stigmatellin was shown to be one of the strongest protectors against the Cd2+-induced cell damage, producing a 15–20% increase in the cell viability.
The mechanisms of the mtETC involvement in the heavy-metal-induced mitochondrial membrane permeabilization and cell death are discussed.
American Psychological Association (APA)
Belyaeva, Elena A.& Sokolova, Tatyana V.& Emelyanova, Larisa V.& Zakharova, Irina O.. 2012. Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity : Effects of Cadmium, Mercury, and Copper. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-448535
Modern Language Association (MLA)
Belyaeva, Elena A.…[et al.]. Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity : Effects of Cadmium, Mercury, and Copper. The Scientific World Journal No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-448535
American Medical Association (AMA)
Belyaeva, Elena A.& Sokolova, Tatyana V.& Emelyanova, Larisa V.& Zakharova, Irina O.. Mitochondrial Electron Transport Chain in Heavy Metal-Induced Neurotoxicity : Effects of Cadmium, Mercury, and Copper. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-448535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448535