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Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy
Joint Authors
Nardinelli, Luciana
Novaes, Mafalda M. Y.
Bendit, Israel
Dorliac-Llacer, Pedro Enrique
Conchon, Monika
Serpa, Mariana
Ferreira, Patrícia B.
Sanabani, Sabri S.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-07
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Here we report the case of an 18-year-old woman with chronic myeloid leukemia (CML) who became pregnant while undergoing treatment with dasatinib.
Before pregnancy, she received imatinib mesylate therapy but could not tolerate the treatment.
The regimen was then changed to dasatinib at a dose of 70 mg b.i.d.
While she was in hematological remission and on dasatinib therapy, she became pregnant.
The unplanned pregnancy was identified after the patient had experienced four weeks of amenorrhea.
Because the patient elected to continue the pregnancy to term, dasatinib was stopped immediately.
Meanwhile, CML hematological relapse occurred and then she was treated with interferon-α (IFN-α) (9 million IU/day) throughout the pregnancy without a complete hematological response.
She successfully gave birth to a male baby at 33 weeks by cesarean section delivery with no sequelae or malformations.
Although this experience is limited to a single patient, it provides a useful contribution for counselling patients inadvertently exposed to dasatinib during pregnancy.
American Psychological Association (APA)
Conchon, Monika& Sanabani, Sabri S.& Serpa, Mariana& Novaes, Mafalda M. Y.& Nardinelli, Luciana& Ferreira, Patrícia B.…[et al.]. 2010. Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy. Advances in Hematology،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-448556
Modern Language Association (MLA)
Conchon, Monika…[et al.]. Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy. Advances in Hematology No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-448556
American Medical Association (AMA)
Conchon, Monika& Sanabani, Sabri S.& Serpa, Mariana& Novaes, Mafalda M. Y.& Nardinelli, Luciana& Ferreira, Patrícia B.…[et al.]. Successful Pregnancy and Delivery in a Patient with Chronic Myeloid Leukemia while on Dasatinib Therapy. Advances in Hematology. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-448556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448556