Body Weight Control by a High-CarbohydrateLow-Fat Diet Slows the Progression of Diabetic Kidney Damage in an Obese, Hypertensive, Type 2 Diabetic Rat Model

Abstract EN

Obesity is one of several factors implicated in the genesis of diabetic nephropathy (DN).

Obese, hypertensive, type 2 diabetic rats SHR/NDmcr-cp were given, for 12 weeks, either a normal, middle-carbohydrate/middle-fat diet (MC/MF group) or a high-carbohydrate/low-fat diet (HC/LF group).

Daily caloric intake was the same in both groups.

Nevertheless, the HC/LF group gained less weight.

Despite equivalent degrees of hypertension, hyperglycemia, hyperlipidemia, hyperinsulinemia, and even a poorer glycemic control, the HC/LF group had less severe renal histological abnormalities and a reduced intrarenal advanced glycation and oxidative stress.

Mediators of the renoprotection, specifically linked to obesity and body weight control, include a reduced renal inflammation and TGF-beta expression, together with an enhanced level of adiponectin.

Altogether, these data identify a specific role of body weight control by a high-carbohydrate/low-fat diet in the progression of DN.

Body weight control thus impacts on local intrarenal advanced glycation and oxidative stress through inflammation and adiponectin levels.