The Natural Stilbenoid Piceatannol Decreases Activity and Accelerates Apoptosis of Human Neutrophils : Involvement of Protein Kinase C
Joint Authors
Svitekova, Klara
Jančinová, Viera
Perečko, Tomáš
Nosál’, Radomír
Drábiková, Katarína
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Neutrophils are able to release cytotoxic substances and inflammatory mediators, which, along with their delayed apoptosis, have a potential to maintain permanent inflammation.
Therefore, treatment of diseases associated with chronic inflammation should be focused on neutrophils; formation of reactive oxygen species and apoptosis of these cells represent two promising targets for pharmacological intervention.
Piceatannol, a naturally occurring stilbenoid, has the ability to reduce the toxic action of neutrophils.
This substance decreased the amount of oxidants produced by neutrophils both extra- and intracellularly.
Radicals formed within neutrophils (fulfilling a regulatory role) were reduced to a lesser extent than extracellular oxidants, potentially dangerous for host tissues.
Moreover, piceatannol did not affect the phosphorylation of p40phox—a component of NADPH oxidase, responsible for the assembly of functional oxidase in intracellular (granular) membranes.
The stilbenoid tested elevated the percentage of early apoptotic neutrophils, inhibited the activity of protein kinase C (PKC)—the main regulatory enzyme in neutrophils, and reduced phosphorylation of PKC isoforms α, βII, and δ on their catalytic region.
The results indicated that piceatannol may be useful as a complementary medicine in states associated with persisting neutrophil activation and with oxidative damage of tissues.
American Psychological Association (APA)
Jančinová, Viera& Perečko, Tomáš& Nosál’, Radomír& Svitekova, Klara& Drábiková, Katarína. 2013. The Natural Stilbenoid Piceatannol Decreases Activity and Accelerates Apoptosis of Human Neutrophils : Involvement of Protein Kinase C. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448577
Modern Language Association (MLA)
Jančinová, Viera…[et al.]. The Natural Stilbenoid Piceatannol Decreases Activity and Accelerates Apoptosis of Human Neutrophils : Involvement of Protein Kinase C. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-448577
American Medical Association (AMA)
Jančinová, Viera& Perečko, Tomáš& Nosál’, Radomír& Svitekova, Klara& Drábiková, Katarína. The Natural Stilbenoid Piceatannol Decreases Activity and Accelerates Apoptosis of Human Neutrophils : Involvement of Protein Kinase C. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-448577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448577