Replacements of Rare Herbs and Simplifications of Traditional Chinese Medicine Formulae Based on Attribute Similarities and Pathway Enrichment Analysis
Joint Authors
Wen, Chengping
Fang, Zhao
Shi, Tieliu
Yi, Zhenghui
Zhang, Meixia
Qian, Min
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A Traditional Chinese Medicine (TCM) formula is a collection of several herbs.
TCM formulae have been used to treat various diseases for several thousand years.
However, wide usage of TCM formulae has results in rapid decline of some rare herbs.
So it is urgent to find common available replacements for those rare herbs with the similar effects.
In addition, a formula can be simplified by reducing herbs with unchanged effects.
Based on this consideration, we propose a method, called “formula pair,” to replace the rare herbs and simplify TCM formulae.
We show its reasonableness from a perspective of pathway enrichment analysis.
Both the replacements of rare herbs and simplifications of formulae provide new approaches for a new formula discovery.
We demonstrate our approach by replacing a rare herb “Forsythia suspensa” in the formula “the seventh of Sang Ju Yin plus/minus herbs (SSJY)” with a common herb “Thunberg Fritillary Bulb” and simplifying two formulae, “the fifth of Du Huo Ji Sheng Tang plus/minus herbs (FDHJST)” and “Fang Feng Tang” (FFT) to a new formula “Fang Feng Du Huo Tang” (FFDHT).
American Psychological Association (APA)
Fang, Zhao& Zhang, Meixia& Yi, Zhenghui& Wen, Chengping& Qian, Min& Shi, Tieliu. 2013. Replacements of Rare Herbs and Simplifications of Traditional Chinese Medicine Formulae Based on Attribute Similarities and Pathway Enrichment Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448588
Modern Language Association (MLA)
Fang, Zhao…[et al.]. Replacements of Rare Herbs and Simplifications of Traditional Chinese Medicine Formulae Based on Attribute Similarities and Pathway Enrichment Analysis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-448588
American Medical Association (AMA)
Fang, Zhao& Zhang, Meixia& Yi, Zhenghui& Wen, Chengping& Qian, Min& Shi, Tieliu. Replacements of Rare Herbs and Simplifications of Traditional Chinese Medicine Formulae Based on Attribute Similarities and Pathway Enrichment Analysis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-448588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448588