Band 3 Missense Mutations and Stomatocytosis : Insight into the Molecular Mechanism Responsible for Monovalent Cation Leak
Joint Authors
Guizouarn, Hélène
Barneaud-Rocca, Damien
Pellissier, Bernard
Borgese, Franck
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Missense mutations in the erythroid band 3 protein (Anion Exchanger 1) have been associated with hereditary stomatocytosis.
Features of cation leaky red cells combined with functional expression of the mutated protein led to the conclusion that the AE1 point mutations were responsible for Na+ and K+ leak through a conductive mechanism.
A molecular mechanism explaining mutated AE1-linked stomatocytosis involves changes in AE1 transport properties that become leaky to Na+ and K+.
However, another explanation suggests that point-mutated AE1 could regulate a cation leak through other transporters.
This short paper intends to discuss these two alternatives.
American Psychological Association (APA)
Barneaud-Rocca, Damien& Pellissier, Bernard& Borgese, Franck& Guizouarn, Hélène. 2011. Band 3 Missense Mutations and Stomatocytosis : Insight into the Molecular Mechanism Responsible for Monovalent Cation Leak. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-448597
Modern Language Association (MLA)
Barneaud-Rocca, Damien…[et al.]. Band 3 Missense Mutations and Stomatocytosis : Insight into the Molecular Mechanism Responsible for Monovalent Cation Leak. International Journal of Cell Biology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-448597
American Medical Association (AMA)
Barneaud-Rocca, Damien& Pellissier, Bernard& Borgese, Franck& Guizouarn, Hélène. Band 3 Missense Mutations and Stomatocytosis : Insight into the Molecular Mechanism Responsible for Monovalent Cation Leak. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-448597
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448597