Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action
Joint Authors
Lancha, Antonio Herbert
da Luz, Claudia Ribeiro
Voltarelli, Vanessa Azevedo
Chaves, Daniela Fojo Seixas
Nicastro, Humberto
Rogero, Marcelo Macedo
Bechara, Luiz Roberto Grassmann
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Skeletal muscle protein turnover is modulated by intracellular signaling pathways involved in protein synthesis, degradation, and inflammation.
The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover.
In this context, branched-chain amino acids (BCAAs), especially leucine, have been described as a strong nutritional stimulus able to enhance protein translation initiation and attenuate proteolysis.
Furthermore, under inflammatory conditions, BCAA can be transaminated to glutamate in order to increase glutamine synthesis, which is a substrate highly consumed by inflammatory cells such as macrophages.
The present paper describes the role of inflammation on muscle remodeling and the possible metabolic and cellular effects of BCAA supplementation in the modulation of inflammatory status of skeletal muscle and the consequences on protein synthesis and degradation.
American Psychological Association (APA)
Nicastro, Humberto& da Luz, Claudia Ribeiro& Chaves, Daniela Fojo Seixas& Bechara, Luiz Roberto Grassmann& Voltarelli, Vanessa Azevedo& Rogero, Marcelo Macedo…[et al.]. 2012. Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448614
Modern Language Association (MLA)
Nicastro, Humberto…[et al.]. Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-448614
American Medical Association (AMA)
Nicastro, Humberto& da Luz, Claudia Ribeiro& Chaves, Daniela Fojo Seixas& Bechara, Luiz Roberto Grassmann& Voltarelli, Vanessa Azevedo& Rogero, Marcelo Macedo…[et al.]. Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-448614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448614