Low Birth Weight due to Intrauterine Growth Restriction andor Preterm Birth : Effects on Nephron Number and Long-Term Renal Health
Joint Authors
Zohdi, Vladislava
Lim, Kyungjoon
Gubhaju, Lina
Sutherland, Megan R.
Zimanyi, Monika A.
Black, M. Jane
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease.
A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning of life.
Importantly, nephrons are only formed early in life; during normal gestation, nephrogenesis is complete by about 32–36 weeks, with no new nephrons formed after this time during the lifetime of the individual.
Hence, given that a loss of a critical number of nephrons is the hallmark of renal disease, an increased severity and acceleration of renal disease is likely when the number of nephrons is already reduced prior to disease onset.
Low birth weight can result from intrauterine growth restriction (IUGR) or preterm birth; a high proportion of babies born prematurely also exhibit IUGR.
In this paper, we describe how IUGR and preterm birth adversely impact on nephrogenesis and how a subsequent reduced nephron endowment at the beginning of life may lead to long-term risk of renal disease, but not necessarily hypertension.
American Psychological Association (APA)
Zohdi, Vladislava& Sutherland, Megan R.& Lim, Kyungjoon& Gubhaju, Lina& Zimanyi, Monika A.& Black, M. Jane. 2012. Low Birth Weight due to Intrauterine Growth Restriction andor Preterm Birth : Effects on Nephron Number and Long-Term Renal Health. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-448615
Modern Language Association (MLA)
Zohdi, Vladislava…[et al.]. Low Birth Weight due to Intrauterine Growth Restriction andor Preterm Birth : Effects on Nephron Number and Long-Term Renal Health. International Journal of Nephrology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-448615
American Medical Association (AMA)
Zohdi, Vladislava& Sutherland, Megan R.& Lim, Kyungjoon& Gubhaju, Lina& Zimanyi, Monika A.& Black, M. Jane. Low Birth Weight due to Intrauterine Growth Restriction andor Preterm Birth : Effects on Nephron Number and Long-Term Renal Health. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-448615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448615