Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing
Joint Authors
Tanaka, Yuriko
Nishio, Naomi
Isobe, Ken-ichi
Liu, Lintao
Ito, Sachiko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The growth arrest and DNA damage-inducible protein, GADD34, has been proved to be involved in TGF-β signaling pathway and correlates with cell death, which are two important mechanisms in regulating myofibroblast differentiation and apoptosis during tissue repair.
But roles of GADD34 in myofibroblasts differentiation and apoptosis remain unknown.
To investigate the function of GADD34 in these processes, we subjected WT and GADD34−/− mice to dermal wound healing.
Here we show that GADD34−/− mice exhibited accelerated wound closure compared with WT mice.
In addition, GADD34−/− mice showed increased number of myofibroblasts, elevated collagen production, and decreased cell apoptosis during wound healing.
Moreover, we found that GADD34−/− mice showed increased phosphorylation of Smad3 and lower level of cleaved caspase-3.
Thus these results indicate that GADD34 appears to suppress myofibroblast differentiation through inhibiting Smad3-dependent TGFβ signal pathway and promote its apoptosis by activating caspase-3 pathway.
American Psychological Association (APA)
Liu, Lintao& Nishio, Naomi& Ito, Sachiko& Tanaka, Yuriko& Isobe, Ken-ichi. 2014. Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-448625
Modern Language Association (MLA)
Liu, Lintao…[et al.]. Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-448625
American Medical Association (AMA)
Liu, Lintao& Nishio, Naomi& Ito, Sachiko& Tanaka, Yuriko& Isobe, Ken-ichi. Negative Regulation of GADD34 on Myofibroblasts during Cutaneous Wound Healing. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-448625
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448625