Mediators of Inflammation in Acute Kidney Injury
Joint Authors
Nguyen, Quocan
Akcay, Ali
Edelstein, Charles L.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Acute kidney injury (AKI) remains to be an independent risk factor for mortality and morbidity.
Inflammation is now believed to play a major role in the pathopathophysiology of AKI.
It is hypothesized that in ischemia, sepsis and nephrotoxic models that the initial insult results in morphological and/or functional changes in vascular endothelial cells and/or in tubular epithelium.
Then, leukocytes including neutrophils, macrophages, natural killer cells, and lymphocytes infiltrate into the injured kidneys.
The injury induces the generation of inflammatory mediators like cytokines and chemokines by tubular and endothelial cells which contribute to the recruiting of leukocytes into the kidneys.
Thus, inflammation has an important role in the initiation and extension phases of AKI.
This review will focus on the mediators of inflammation contributing to the pathogenesis of AKI.
American Psychological Association (APA)
Akcay, Ali& Nguyen, Quocan& Edelstein, Charles L.. 2010. Mediators of Inflammation in Acute Kidney Injury. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-448628
Modern Language Association (MLA)
Akcay, Ali…[et al.]. Mediators of Inflammation in Acute Kidney Injury. Mediators of Inflammation No. 2009 (2009), pp.1-12.
https://search.emarefa.net/detail/BIM-448628
American Medical Association (AMA)
Akcay, Ali& Nguyen, Quocan& Edelstein, Charles L.. Mediators of Inflammation in Acute Kidney Injury. Mediators of Inflammation. 2010. Vol. 2009, no. 2009, pp.1-12.
https://search.emarefa.net/detail/BIM-448628
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448628